Open your image in Photoshop
Using Healing Brush click on the spots to remove them
Reduce Noise
Go to Filter - Noise - Reduce Noise
After reducing Noise then simply grab your brush tool and start painting on area where you don't want effect to apply. Paint over the eyes and the mouth
Now grab you Pen tool and draw over the place you want to apply make up, that is the lips, eye etc
After drawing a path using pen tool, right click and make a selection then create a new adjustment layer then color it as desired. create separate layer for each part you want to make up
Well that's it
